Treatment

Over the years many different pharmacological products have been used in the treatment of scabies. These include sulphur ointment, monosulfiram, benzyl benzoate and GBHC (lindane). Permethrin 5% skin application is the treatment of choice for scabies. In the developed world this has been used as first line treatment for a number of years.

Paediatric Use

Unlike other treatments, Permethrin 5% lotion is safe and effective in paediatric patients two months of age and older. Safety and effectiveness in paediatric patients less than two months of age have not been established. Two week old babies have however been treated successfully.

Use in breast feeding and lactation

Permethrin 5 % has a category B risk factor. For lactating women with scabies, permethrin is considered the treatment of choice in the United States and the United Kingdom.
CDC 1998 Guidelines for treatment of sexually transmitted diseases. MMWR 1998;47:1116.
Clinical Effectiveness Group (Association of Genitourinary Medicine and the Medical Society for the Study of Venereal Diseases). National guideline for the management of scabies. Sex Transm Inf 1999;75 (Suppl):S767
The risk of foetal toxicity following maternal application of permethrin is likely to be no greater than that for the general population
(Drugs.com (sources include Micromedex™, Wolters Kluwer™))

Cochrane review:

Cochrane Infectious Diseases Group Specialized Register, CENTRAL (The Cochrane Library 2006, Issue 1), MEDLINE, EMBASE, LILACS, and INDMED, March 2007:

Interventions for treating scabies

Scabies is a parasitic infection of the skin. It occurs throughout the world, but is particularly problematic in areas of poor sanitation, overcrowding, and social disruption, and is endemic in many resource-poor countries. The global prevalence of scabies is estimated at 300 million cases, but the level of infection varies between countries and communities. The female mite burrows into the skin to lay eggs which then hatch out and multiply. The infection can spread from person to person via direct skin contact, including sexual contact. It causes intense itching with eruptions on the skin. Various drugs have been developed to treat scabies, and herbal and traditional medicines are also used. The review of trials attempted to cover all these. The authors identified 20 small trials involving 2392 people, with 17 of the trials taking place in resource-poor countries. Permethrin appeared to be the most effective topical treatment for scabies and ivermectin appeared to be an effective oral treatment. However, ivermectin is unlicensed for this indication in many countries. Adverse events such as rash, vomiting, and abdominal pain were reported, but the trials were too small to properly assess serious but rare potential adverse effects. No trials of herbal or traditional medicines were identified for inclusion.



Other treatments

  • Benzyl Benzoate Lotion
    Despite its side effect profile, BBL has been used for scabies for more than 50 years. It is effective in treating scabies but needs more than one application and possibly a second treatment within two weeks. This compromises compliance and ultimately the outcome. It's important to note that benzyl benzoate is not commercially available in the U.S. and Canada for the treatment of scabies due to toxicity.
  • Lindane
    Lindane (gamma benzene hexachloride) is an a chlorinated hydrocarbon and banned by the MCC for the treatment of scabies in South Africa due to toxicity on the nervous system.
  • Monosulfiram
    Mostly used in the form of a soap but not effective on its own. Not allowed by the FDA due to toxicity.
  • Ivermectin (Not available in RSA)
    This oral medication is an alternative scabicide that does not require creams to be applied. The CDC recommends taking this drug at a dosage of 200 micrograms per kilogram body weight as a single dose, followed by a repeat dose two weeks later. Although taking a drug by mouth is more convenient than application of the cream, ivermectin has a greater risk of toxic side effects than permethrin and has not been shown to be superior to permethrin in eradicating scabies.



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